O'dell JR, Elliott JR, Mallek JA, Mikuls TR, Weaver CA, Glickstein S, Blakely KM, Hausch R, Leff RD

Treatment of early seropositive rheumatoid arthritis: Doxycycline plus methotrexate versus methotrexate alone

Arthritis Rheum. 2006 Feb;54(2):621-7.

In patients with early seropositive RA, initial therapy with MTX plus doxycycline was superior (based on an ACR50 response) to treatment with MTX alone.

University of Nebraska Medical Center, Omaha.