Scleroderma Minocycline Study:

6 out of 11 patients with early, but severe diffuse scleroderma finished 1 year of minocycline. At the end of 1 year, 4 of the 6 had complete resolution of their skin disease and 3 of the 4 had normal patient and physician assessments. These results are significantly superior to those normally seen in drug studies for scleroderma patients. C Le, A Morales, DE Trentham, Minocycline in Early Diffuse Scleroderma, Lancet, 1998, 352:9142, pgs. 1755-1756.