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PCR Detection of Mycoplasma in Patients with Chronic Fatigue, Fibromyalgia, Rheumatoid Arthritis and Gulf War Syndrome - 1999

The present study suggests that mycoplasma infection may be the common link between these illnesses responsible in some degree for the similarities in symptoms experienced in each condition.

Presence of mycoplasma genus was found in 52% CFS; 54% FMS; 49% RA; and 55% GWS and only 15% of healthy controls. Further testing conducted for three mycoplasma strains proved positive in rheumatoid disease patients with overlapping symptoms. Strains tested were: M. fermentans, M. hominis, and M. Penetrans.

PCR provides a quick, accurate means of testing for mycoplasma with a degree of specificity unmatched by other techniques. Testing with multiplex PCR increases the ability of clinicians to determine the causative agent in diseases with an unknown etiology, and investigate a more complete view of the role of mycoplasma infection in chronic illnesses with similar, overlapping symptoms.

Aristo Vojdani, Al Robert Franco, Multiplex PCR for the detection of Mycoplasma Fermentans. M. Hominis, and M. Penetrans in Patients with Chronic Fatigue Syndrome, Fibromyalgia, Rheumatoid Arthritis, and Gulf War Syndrome J Chronic Fatigue, 1999; Vol. 5, No. 3/4, p 187-197.